Last data update: May 13, 2024. (Total: 46773 publications since 2009)
Records 1-2 (of 2 Records) |
Query Trace: Vogt Jr RF[original query] |
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Human peripheral blood B-cell compartments: A crossroad in B-cell traffic
Perez-Andres M , Paiva B , Nieto WG , Caraux A , Schmitz A , Almeida J , Vogt Jr RF , Marti GE , Rawstron AC , Van Zelm MC , Van Dongen JJ , Johnsen HE , Klein B , Orfao A . Cytometry B Clin Cytom 2010 78 Suppl 1 S47-60 A relatively high number of different subsets of B-cells are generated through the differentiation of early B-cell precursors into mature B-lymphocytes in the bone marrow (BM) and antigen-triggered maturation of germinal center B-cells into memory B-lymphocytes and plasmablasts in lymphoid tissues. These B-cell subpopulations, which are produced in the BM and lymphoid tissues, recirculate through peripheral blood (PB), into different tissues including mucosa and the BM, where long-living plasma cells produce antibodies. These circulating PB B-cells can be classified according to their maturation stage into i) immature/transitional, ii) naive, and iii) memory B-lymphocytes, and iv) plasmablasts/plasma cells. Additionally, unique subsets of memory B-lymphocytes and plasmablasts/plasma cells can be identified based on their differential expression of unique Ig-heavy chain isotypes (e.g.: IgM, IgD, IgG, IgA). In the present paper, we review recent data reported in the literature about the distribution, immunophenotypic and functional characteristics of these cell subpopulations, as well as their distribution in PB according to age and seasonal changes. Additional information is also provided in this regard based on the study of a population-based cohort of 600 healthy adults aged from 20 to 80 years, recruited in the Salamanca area in western Spain. Detailed knowledge of the distribution and traffic of B-cell subsets through PB mirrors the immune status of an individual subject and it may also contribute to a better understanding of B-cell disorders related to B-cell biology and homeostasis, such as monoclonal B-cell lymphocytosis (MBL). |
Evolution of a precursor
Caporaso NE , Marti GE , Vogt Jr RF , Shim YK , Middleton D , Landgren O . Cytometry B Clin Cytom 2010 78 (1) 1-3 Many investigators had previously noted collections of CLL-like cells in various clinical settings and reported their observations with colorful descriptors (1) but their precise clinical, population, and phenotypic characteristics were poorly understood. A unifying nomenclature was lacking before 2005 when a group of international investigators forged the terminology and definition of Monoclonal B-Cell Lymphocytosis or “MBL” and consolidated the observations available at that time (2). | As is often the case in science, this permitted rapid progress. Today an increasing number of reports document a steadily expanding understanding. The following are now well-appreciated: | MBL is more common in the elderly and in high-risk B cell malignancy (CLL) kindreds; | MBL precedes virtually all cases of CLL (3); | MBL has strong parallels with MGUS and myeloma as a B-cell precursor (4); | “Low count MBL” with a normal absolute B-cell count has limited potential to progress to CLL (5); |
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